NAD+ — nicotinamide adenine dinucleotide — is a coenzyme found in every cell, central to energy metabolism and to enzymes involved in cellular signaling and DNA repair. That biological importance is exactly why NAD+ has become such a hot topic in aging and wellness circles.
What NAD+ does in the body
The key distinction is between what NAD+ does inside normal biology and what an NAD+ infusion has actually been shown to do for a person.
What the evidence shows
A February 2026 PRISMA-guided systematic review in Ageing Research Reviews looked at 113 intervention studies — 33 in humans, 80 in rodents — spanning 2010 through October 2025. Its conclusion: NAD+ augmentation shows clear biological activity, but clinical effectiveness for anti-aging or wellness outcomes remains inconclusive. Notably, the review found no eligible controlled outcome trials of intravenous, intramuscular, or subcutaneous NAD+ itself for anti-aging or wellness indications — the human data that exists is almost entirely about oral precursors like nicotinamide riboside and nicotinamide mononucleotide, not IV NAD+.
Safety and tolerability
Safety data on IV NAD+ specifically is also thin. A 2026 retrospective tolerability study comparing commercially administered IV NAD+ to IV nicotinamide riboside found that participants who received NAD+ IV reported moderate to severe gastrointestinal symptoms, increased heart rate, and chest pressure during infusions, symptoms that resolved once the infusion ended. Moderate to severe symptoms with NAD+ IV also meant longer infusion times — averaging 97 minutes versus 37 minutes for NR IV.
None of this means NAD+ is a scam or that people don’t report feeling something during or after an infusion. It means the claims made about it should stay tethered to what’s actually been studied. NAD+ has not been shown to reverse aging, lengthen telomeres, treat dementia, repair every cell, detoxify the liver, prevent disease, or reliably improve energy and cognition — none of that is established. Clients should understand both the uncertainty and the realistic chance of infusion discomfort before they book.
At Arizona IV
NAD+ infusions are offered in 250 mg, 500 mg, and 750 mg options. Clients typically come to this looking for the cellular-metabolism angle — and that part of the biology is real. What isn’t established is clinical effectiveness for anti-aging, energy, or cognition specifically from the IV route. Screening, dosing, and infusion rate are handled by our clinical team, with an honest conversation about tolerability up front.
Sources
- Gallagher, C. & Emmanuel, O.O., NAD⁺ Supplementation for Anti-Aging and Wellness: A PRISMA-Guided Systematic Review of Preclinical and Clinical Evidence, Ageing Research Reviews, 2026
- Reyna, K. et al., Intravenous Infusion of Nicotinamide Adenine Dinucleotide (NAD+) Versus Nicotinamide Riboside (NR): A Retrospective Tolerability Pilot Study in a Real-World Setting, Frontiers in Aging, 2026
This information is provided for general educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure or prevent any disease. IV therapy is not appropriate for everyone. Services are provided only after clinical screening. If you may be experiencing a medical emergency, call 911 or seek emergency care.